Distribution of Antibodies to Native DNA,Single-Stranded DNA,and Double-Stranded RNA in Mouse Serums 1

Abstract

Summary

Hemagglutinating antibodies to native DNA were found to occur selectively in NZB/W mice and rarely in other strains. In contrast, antibodies to single-stranded DNA and double-stranded RNA have a more widespread distribution. They occur in NZB and NZB/W mice as well as other strains of mice. Poly A·poly U and poly I·poly C are shown to be immunogenic in mice without the use of Freund's adjuvant or in vitro coupling to a protein carrier.