Comparison of Early Hemodynamic Phenomena in Three Forms of Shock in Dogs 1

Abstract

Summary

Response patterns of arterial pressure, cardiac output, venous return, and total peripheral resistance were determined in 3 lethal shock states. Hemorrhagic shock decreased pressure and flows most profoundly and most persistently but increased resistance. Endotoxic shock caused an initial transient decrease in pressure and flows, followed by a later depression of these measurements and also decreased total peripheral resistance. Cardiogenic shock gradually decreased pressure and flows and did not change resistance. The concept of a single early circulatory derangement as the primary cause of irreversibility in shock is not supported by our findings.