Abstract
Discussion and Summary
We had previously described the presence in canine pancreatic juice of several glycosidase enzyme systems. The present data indicate that the outputs of β-glucosaminidase, β-galactosaminidase, α-mannosidase, and α-fucosidase in pancreatic juice increase in response to pancreatic hormonal stimulation to the same degree as those of trypsinogen and amylase. This suggests that these glycosidase enzyme systems may belong to the physiologic complement of enzyme protein in pancreatic juice. It is, of course, important to recognize that the ability of a glycosidase to remove a glycosyl group from a synthetic substrate, which forms the basis of our enzyme assay, does not prove that the enzyme can release the same group from a naturally occurring large molecular substrate. However, the suggestion of a physiologic role for at least one of these enzymes, β-N-acetylglucosaminidase, is strengthened by our finding (to be reported) that this enzyme releases N-acetylglucosamine from ovomucoid.
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