Abstract
Summary
Prior incubation of Salmonella enteritidis lipopolysaccharide with varying concentrations of Triton X100, Tween 20, sodium deoxycholate, sodium taurocholate, and sodium lauryl sulfate markedly reduced lethality of the lead-sensitized rat in endotoxin shock. The inactivation process did not proceed at 4° in comparison to reduction in toxicity during 37° incubation. The possibility of a surfactant serving the physiological reticuloendothelial detoxifying system is presented.
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