Abstract
Summary
Hyperimmunization of rabbits or hamsters with infected suckling mouse brain of various Phlebotomus fever viruses led to the development of viral-specific and nonspecific cross-reacting antibodies which can be detected by immunodiffusion techniques. The cross-reacting antibody(s) was shown also to react with other nonrelated arbovirus antigens. Elucidation of the phenomenon showed that the reaction was not due to C-reactive protein, heterophile, or normal mouse brain antibody; rather it appears to be the result of a modified brain antigen present in the central nervous system following infection with arboviruses.
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