Abstract
Summary
Plasma and urine renin activity were measured in dogs during control diet and sodium deprivation. Renin activity increased in both plasma (p < 0.01) and urine (p < 0.01) in parallel fashion during sodium deprivation and decreased with sodium replacement. In another group of dogs, sodium restriction had the same stimulatory effect on plasma (p < 0.01), urine (p < 0.01), and renal renin activity (p < 0.01). The results indicate that enhanced urinary excretion of renin is directly correlated to the increase in plasma and renal renin activity.
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