Abstract
Summary
Hepatitis was induced in animals treated with D-GalN-HCl (1.5 g/kg) in vitro. Incorporation of alanine-UL-14C, pyruvate-2-14C, and glutamic-3,4-14C acid into glucose by liver slices from GalN-treated animals was found decreased to 20-25% of the control values. The CO2 production from these substrates was impaired by 50%. Activity of gluconeogenic enzymes was measured, PEP carboxykinase and pyruvate carboxylase exhibited the most important changes and FDPase and G-6-Pase were also significantly decreased but failed to respond to fasting. It is suggested that this GalN-induced hepatitis might be a good model to use to reproduce a study of hypoglycemia found sometimes in human viral hepatitis and other liver damage.
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