Abstract
Summary
Metabolic alterations caused by nitroglycerin were compared with those of tranylcypromine. Following administration of 100 μg/kg of nitroglycerin in unanesthetized rabbits, simultaneous elevations of plasma FFA (+98%), glycerol (+53%), lactate (+178%), and pyruvate (+135%) were observed. The same dose of nitroglycerin caused a significant elevation of plasma lactate but failed to increase plasma FFA and glycerol in reserpinized and propranolol-treated rabbits. Tranylcypromine (30 mg/kg) caused similar alterations: increase in plasma FFA (+135%), glycerol (+85%), lactate (+335%), and pyruvate (+152% Similarly, an increase in plasma lactate without change in plasma FFA and glycerol levels, was observed in reserpinized animals. An increase in body temperature was found in nitroglycerin- and tranylcypromine-treated rabbits, This effect was diminished when the two drugs were administered in reserpine-and propranolol-treated rabbits. These results indicate that the rate of lipolysis and glycolysis is increased in rabbits treated with both MAO inhibitors. Unlike glycolysis, increased lipolysis seems to be mediated by endogenous catecholamines.
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