Cardiovascular and Lysosomal Actions of Corticosteroids in the Intact Dog 1

Abstract

Summary

Aldosterone, deoxycorticosterone acetate (DOCA), Cortisol, and methylprednisolone were studied in the vagotomized, baroreceptor denervated dog for hemodynamic actions and lysosomal stabilizing activity in the pancreas. Only aldosterone (0.001 to 0.01 mg/kg) exerted a significant positive inotropic effect. None of the other corticosteroids in doses up to 1 to 40 mg/kg had any detectable effect on mean arterial blood pressure, aortic flow, central venous pressure, or heart rate. Furthermore, the two glucocorticoids (Cortisol and methylprednisolone) significantly stabilized the pancreatic lysosomes both in vivo and in vitro, as determined by the release of β-glucuronidase; whereas neither aldosterone nor DOCA exerted a protective effect on the lysosomal preparations.