Abstract
Summary
Human gamma globulin (HGG) was separated into three fractions following ultracentrifugation: (A) aggregate-free supernatant, (B) heat aggregated supernatant, and (C) sediment. The aggregate-free material proved tolerogenic in rabbits. The aggregated material was immunogenic in all rabbits tested, and the sedimented material was immunogenic in four of seven rabbits. None of these fractions were pyrogenic and therefore considered to be free of contaminating endotoxins.
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