Abstract
Summary
Treatment with the detergent deoxycholate potentiates the rate and extent of the ATP-induced contraction of both thick (485 μ) glycerol-extracted arterial muscle and thick (700 μ) skeletal muscle fiber bundles. Deoxycholate does not affect the ATP-induced contraction of thin glycerol-extracted fiber bundles (180 and 135 μ for arterial muscle and skeletal muscle fiber bundles, respectively) . It does not affect the Ca-induced contraction of arterial muscle fiber bundles pre-equilibrated with 5 mM MgATP, and inhibits the ATPase activity of skeletal muscle actomyosin. It thus appears that the potentiating action of deoxycholate on the contraction of thick glycerol-extracted fiber bundles is due to its ability to enhance the diffusion of ATP through the fiber bundle.
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