Abstract
Summary
Phenylbutazone inhibits hemolysis of canine or human erythrocytes (RBC) when suspensions (40%) of RBC are incubated at 53° for 20 min in 0.067 M sodium phosphate buffer containing isotonic saline. Methysergide and indomethacin are also effective but indomethacin is much less effective in stabilizing human than canine RBC. Stabilization of RBC by phenylbutazone was observed when RBC were incubated at pH 5.0 through 10.0. Much less stabilization was noted at lower or higher pH; at pH 4.0, complete RBC destruction occurs and phenylbutazone is ineffective. Guinea pig, rat, rabbit, horse, and goat RBC were not stabilized by the anti-inflammatory agents.
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