Effect of Heparin on Endotoxin-Induced Thrombocytopenia 1

Abstract

Summary

The generalized Shwartzman reaction in rabbits was used as the in vivo model for endotoxin- and thrombin-induced changes in the WBC, platelets, and fibrinogen concentration. Concentrations of heparin ranging from 1000 to 25,000 units/kg did not alter the effect of heparin on the changes in these hematologic constituents. Leukopenia and thrombocytopenia were produced but fibrinogen consumption did not occur in the presence of heparin. Since the change in the platelets was similar to the leukocytes and not affected by heparin, it was concluded that the mechanism of platelet injury was related to the endotoxin and not to thrombin generation.