Abstract
Summary
Administration of compound 48-80 to PMS-HCG-treated immature rats causes an inhibition of the ovarian weight increase due to the stimulation exerted by HCG. Benadryl causes a slight reduction in this ovarian response but combination with 48/80 results in a profound inhibition. The combined treatment reduced the number of ova shed, but all the rats ovulated. The ovarian histamine content decreased but the blood concentrations rose after treatment with HCG. Histamine apparently plays a major role in the acute increase in ovarian weight but not in ovulation.
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