Suppression by Hepatectomy of Glucagon-Induced Hypertriglyceridemia in Geese 1

Abstract

Summary

Continuous infusion of glucagon (1.0 μg/kg/min for 30 min) in normal geese caused an elevation of plasma FFA and blood sugar and a decrease of plasma TGL concentration. Upon discontinuing glucagon infusion, plasma TGL rose significantly to a peak level 2 hr after the end of infusion.

Functional hepatectomy suppressed the elevations of plasma TGL and blood sugar observed in normal geese infused with glucagon, and produced a continuous decrease of plasma TGL which was not affected by the administration of glucagon.

These results indicate that the elevation of plasma TGL after glucagon infusion is due to increased release of lipoproteins by the liver, induced by the elevation of plasma FFA. The decrease of plasma TGL during the infusion of glucagon and the delay between the elevations of plasma FFA and plasma TGL suggest that glucagon, in addition to its adipokinetic effect, decreases the release of TGL by the liver into the circulation.