Abstract
Summary
Renal ATPase activity was measured in rabbits of different ages. Total Na,K-activated; Mg-dependent-ATPase activity increased gradually with age from newborn to adult. Mg-dependent-ATPase, however, remained essentially unchanged and equivalent to the adult level during development. Na,K-activated-ATPase was nearly absent at birth and at 5 weeks of age approached levels comparable to those of the adult. The increase in total ATPase activity was due to this selective increase in the Na,K-activated component. The development of Na,K-activated-ATPase activity correlates well with the reported maturation of renal transport mechanisms for amino acids, p-aminohippuric acid, and sodium ion during the perinatal period.
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