The Inhibition of Intestinal Absorption of Phenylalanine in the Rhesus Monkey

Abstract

Summary

β-2-Thienylalanine, cycloleucine, and parachlorophenylalanine have been shown to acutely reduce intestinal absorption of an oral phenylalanine load. Combined with phenylalanine, they reduce plasma tryptophan levels more than phenylalanine alone.

Whether their oral administration will be of benefit in allowing a more liberal diet in phenylketonuric children requires more investigation.