Abstract
Summary
The relationship between H and K output from vagally denervated fundic pouches under steady-state histamine stimulation was determined when secretion was either inhibited by two pharmacologic agents—atropine and cyproheptadine—or the dose of histamine was lowered. The correlation between H and K decline exceeded 0.9 with all three techniques. There was poor correlation between the change in H output and Na output. These findings suggest that gastric H and K secretion are coupled. The relevance of this coupling to a proposed electrogenic mechanism for gastric H secretion is noted. Inhibition of histamine-stimulated gastric secretion with the agents employed altered the pattern of gastric electrolyte secretion in a manner different from that of acetazolamide inhibition.
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