Effect of Long-Term Hypoxia on Protein Synthesis in Granuloma and in Some Organs in Rats

Abstract

Summary

In rats adapted first to hypoxia simulating 7000-m altitude, further exposures to low oxygen tensions stimulated collagen synthesis only in the granuloma tissue and had no effect on the degradation of collagen. The polymerization of soluble forms into less soluble collagen was decreased. In the liver and lung, collagen synthesis did not change. In the heart and small intestine, collagen synthesis was significantly decreased. The formation of noncollagenous proteins was significantly inhibited in all tissues studied. No effect of hypoxia on hydroxylations of collagenous proline was observed.