Abstract
Summary
Histologically normal isolated, short-circuited rabbit ileum absorbed both sodium and chloride ions. Structurally damaged mucosa did not absorb either ion. Glucose mediated short-circuit current effect was present in normal but was much reduced in abnormal tissues. These findings in tissue with altered structure were compared to tissue exposed to cholera toxin, where no net sodium absorption occurs yet net chloride movement from serosal-to-mucosal surfaces occur. In contrast to the pathological tissues the absent net sodium absorption in cholera is reversible with the addition of glucose to the mucosal medium.
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