Abstract
Summary
The adjuvant arthritis test was used as a model to measure the effect of Aldactone on the ulcerogenic and antiinflammatory activities of Indocin. It was demonstrated that Aldactone can abolish the ulcerogenic activity of Indocin while causing only a limited depression of the anti-inflammatory activity. Aldactone, therefore, may be useful in the clinic in reducing the gastrointestinal irritation caused by Indocin treatment.
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