Abstract
Summary
The purpose of this study was to determine whether preexisting atrophic gastritis and high intragastric pH render the gastric mucosa more or less susceptible to the ulcerogenic effects of parenteral aspirin. Radiation-induced gastric atrophy was used to produce achlorhydria in rats. Properly shielded rats received 1750 rads to the eviscerated stomach. Paired controls were subjected to a sham procedure. By comparison with the paired controls, all the irradiated rats became achlorhydric. When challenged with aspirin given parenterally (600 mg/kg/day in 4 divided doses over 2 consecutive days), the average number of gastric erosions in the sham irradiated control animals was 10, while the average number of erosions in the irradiated animals was 0.25. The data suggest that gastric HCl plays an important role in the phenomenon of gastric mucosal injury by parenterally administered aspirin.
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