Abstract
Summary
Diploid human fibroblasts from patients with diagnosed fibrocystic disease differed markedly in their ability in vitro to synthesize collagen and induce collagenolytic activity from cells derived from either normal human skin, embryonic lung, or from the skin of two patients with acid mucopolysaccharidoses.
Increasing amounts of ascorbic acid caused normal fibroblasts to increase their synthesis of collagen by about 150 to 300%: “Fibrocystic” fibroblasts increased their synthesis of collagen by only about 20 to 50%. The “fibrocystic” fibroblasts in vitro also induced about 1/2 as much collagenolytic activity with oxyphenylbutazone as did non-“fibrocystic” fibroblasts.
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