Abstract
Summary
In isolated cat heart preparations, ACh in doses of 10-4 g elicits a positive inotropic response. This response is blocked by cocaine. It appears that the blockade of the response by cocaine is similar to cocaine blockade of the response to indirect acting amines, e.g., tyramine. This is further evidence that the positive inotropic effect of ACh in ventricular myocardium is mediated by NE release.
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