Abstract
Summary
Restraint-stress was induced in female CFE rats weighing between 150 and 200 g by stapling them in envelopes made of aluminum wire screening. Five mg of bovine growth hormone dissolved in 1 ml of buffer was administered subcutaneously immediately after stapling and again 10 hr later. Controls received injections of buffer or bovine serum albumin. The animals were sacrificed at 24 hr and the number of animals developing gastric erosions, the number per animal and the severity of erosions were determined with a dissecting microscope. Growth hormone provides partial but significant protection against the production of restraint-stress produced erosions, both in terms of incidence of erosions and their severity.
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