Abstract
Summary
Suspensions of cultured human liver cells (Chang) were exposed to 1 of 7 phenothiazines at concentrations ranging from 10-5 to 10-3 M, for a period of 30 min. Identical preparations of cells without drugs served as the controls. The levels of three enzymes (lactate dehydrogenase, malate dehydrogenase and aspartate aminotransferase) were measured in the medium and cells. The differences between the controls and drug preparations were considered to be the result of cytotoxic effects of the drugs. In this model, the trifluoperazine, thioridazine, and triflupromazine showed the greatest cytotoxic potency; promazine and promethazine showed the least potent cytotoxic effect, and chlorpromazine and fluphenazine were of intermediate potency. The possible relationship between these effects of the respective phenothiazines and their chemical structure was considered.
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