Abstract
Summary
The synthetic double-stranded RNA, polyinosinic: polycytidylic acid (poly I:poly C), strongly inhibits in vivo RNA and protein synthesis in three different tumors in mice. Macromolecule synthesis in normal organs of these mice may be inhibited or enhanced, depending to some extent on the strain of mouse. Administration of poly I:poly C to the mice also leads to alterations in the specific radioactivity of acid-soluble precursor pools, sometimes increasing and sometimes decreasing such specific activity. There was no discernible relationship between the nature of the alteration in precursor specific activity and the direction of effect on macro-molecule synthesis.
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