Abstract
Summary
A cell-suspension system was utilized to study the effect of PTH and pitressin on the cyclic AMP concentration in renal cells. Cyclic AMP increased in the presence of either hormone. These findings support the view that cyclic AMP is involved in the mechanism of action of these hormones in the kidney and that this action might be brought about through a direct effect on the metabolism of the renal cells. It is suggested that the renal-cell suspension system might prove to be a versatile tool in renal physiology.
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