Abstract
Summary
Low concentrations (10-9 to 10-8 M) of Cortisol strongly stimulate the proliferation of rat thymocytes maintained in vitro by a process which involves cyclic AMP. On the other hand, cortisol concentrations greater than 10-7 M inhibit cell proliferation. The steroid's stimulatory effect may be due to sensitization of the cells to the mitogenic action of cyclic AMP.
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