Abstract
Summary
The pressor activity of the plasma of the renal venous effluent of rats rendered acutely hypertensive by focal infarction of the kidney has been demonstrated. The pressor effect is transient and is due to the elaboration of an agent which can be differentiated from renin and angiotensin. The rat, accordingly, resembles the dog and man in manifesting a form of acute hypertension which differs from chronic hypertension in being mediated by a previously unrecognized pressor agent elaborated by the kidney. As in the dog and man, the pressor agent may be demonstrated in the renal venous effluent. Its concentration in the peripheral blood is proportional to the observed elevation in blood pressure. The pressor effect and rise in blood pressure appear within a day after focal infarction of the kidney and last for about 30 days.
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