Abstract
Summary
Carrageenan, a known granuloma-producing agent with macrophage-toxic properties, was substituted for M. tuberculosis, a macrophage stimulant, in complete Freund's adjuvant. Carrageenan failed to enhance delayed hypersensitivity or γ2 anti-BSA production when compared with M. tuberculosis over a wide dose range. Histologically, draining nodes from carrageenan-inoculated animals revealed little hyperplasia when compared with extensive epithelioid cell infiltrates in nodes from animals receiving complete Freund's adjuvant.
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