Abstract
Summary
Rats receiving 12.5 mg of chlorcyclizine/kg of body weight and 15% ethanol (w/v) as the sole source of drinking fluid for 31 days showed a significant accumulation of hepatic triglycerides. Administration of chlorcyclizine alone led to only a slight increase in liver lipids while a group receiving alcohol failed to show any significant changes. Chronic administration of chlorcyclizine seemed to increase the tolerance to alcohol as reflected by the increased alcohol consumption in the presence of the drug.
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