Abstract
Summary
The concentration of E-ACA in the joint fluid and joint capsule was measured at different intervals after iv injection of the substance in a dose of 0.1 g/kg body weight in 16 patients undergoing operation because of a ruptured meniscus of the knee joint. It was found that E-ACA diffuses to both of the above-mentioned tissues and that some E-ACA can be demonstrated in the tissues for up to 16 hr after injection. A dose of 0.1 g/kg body weight 4–6 times a day orally or intravenously is recommended in the treatment of joint hemorrhages in patients with hemophilia.
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