Abstract
Summary
Six antiandrogens were compared for ability to inhibit the stimulant effect of testosterone on chick comb weight. Relative potencies could not be determined exactly because of nonparallelism of the dose-response curves. Based upon the maximal inhibitions observed, relative potencies were as follows: cyproterone acetate > Ro 5–2537 > methyl, B-nortestosterone > Ro 2–7239 > cyproterone (free OH). A-Norprogesterone was inactive as an antiandrogen at dosages up to 27 × T on a molar basis.
Get full access to this article
View all access options for this article.