Characterization of Four New Rhinovirus Serotypes 1

Abstract

Discussion and Summary

The isolation and characterization of 4 new rhinovirus serotypes, including the prototype strain of RV83 (Baylor 7), strains of RV56 (Baylor 5) and RV64 (Baylor 6), and a new rhinovirus serotype to be submitted to phase III of the Rhinovirus Collaborative Program have been described. All of the viruses exhibited the essential properties of a rhinovirus: small size, RNA core, acid lability, and ether stability. All were nonpathogenic for mice and failed to hemagglutinate red blood cells. All were isolated from young adults with the common cold in tissue culture cells of human origin (WI-38, HEK, and human aorta) and all grew best rolled at 33°. Baylor 5 had a buoyant density in cesium chloride of approximately 1.39 g/cm³. Of particular note is the fact that although 34 new rhinovirus serotypes were just recently added to the numbering system to bring the total number of rhinovirus serotypes classified to 89, Baylor 8 assures the continued expansion of the numbering system.