Abstract
Summary
Fasted rats were injected with either saline, pentagastrin (125 μg/kg) or pentagastrin plus secretin (75 units/kg) and killed 90 min later. Pentagastrin and the combination of pentagastrin and secretin released 50% of the histamine contained in the wall of the oxynitc gland area of the stomach. Therefore, secretin does not inhibit gastrin-stimulated secretion by inhibiting histamine release as has been hypothesized, Since this dose of secretin completely inhibits acid secretion stimulated by 125 μg/kg of pentagastrin in rats but has no effect on a comparable amount of histamine stimulated secretion, we conclude that gastrin stimulates the parietal cell without the intervention of histamine.
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