Abstract
Summary
Human diploid cells (peripheral leukocytes and fibroblasts) infected with measles, Sendai, h. zoster, and h. simplex type 2 viruses showed chromosome pulverization, usually in polyploid cells. Autoradiography indicated that the pulverized chromatin replicated later than the normal chromosomes, and that susceptible nuclei may be in the S, G2 (or G1) phase of cell replication. It is hypothesized that pulverization may result from premature chromosome condensation induced by a diffusible substance.
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