Abstract
Summary and Conclusions
An experimental model was designed to test the relative roles of histamine-induced gastric hypersecretion and steroid-induced reduced mucosal resistance, in acute gastroduodenal ulceration. Reduction of dosage of histamine reduces the frequency of deaths due to perforated duodenal ulcer. Addition of hydrocortisone eliminates this change in mortality. Clinical correlation is discussed.
The results provide further evidence for the hypothesis that, in the presence of reduced mucosal resistance, peptic digestion is still necessary for ulceration.
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