Synthetic and Secretory Effects of Cholecystokinin-Pancreozymin on the Pigeon Pancreas 1,2,3

Abstract

Conclusion

Studies of effects of cholecystokinin-pancreozymin on pancreatic secretion and synthesis have revealed the following: 40 Ivy units/kg iv to fed or fasted pigeons, enhances secretion without an effect on synthesis; 100 Ivy units/kg to fed pigeons, enhances secretion without change in synthesis; 100 Ivy units/kg doses to 3-day fasted pigeons, enhances secretion as well as synthesis. In order to elicit a synthetic response in the pigeon with intravenous cholecystokinin-pancreozymin, large doses as well as previously fasted animals were required.

These studies indicate that secretory and synthetic responses can be disassociated. The results support the thesis that while synthesis and secretion frequently change in a parallel fashion they can be disassociated and most likely, therefore, have independent, though integrated, control systems.