Abstract
Summary
Post X-irradiation rat-into-mouse chimeras were produced after treatment of the donors with rabbit antirat lymphocyte serum (RARLS) or the in vitro incubation of rat bone marrow cells with RARLS. The survival rate in both groups of animals was poor, with none of the animals surviving beyond 4 weeks. The in vitro synthesis of donor-type serum proteins by the lymphoid tissues of the host was demonstrated by the technique of radioimmunoelectrophoresis. There were no significant differences in the in vitro synthesis of serum proteins of donor type in the two groups of animals.
There was no correlation between the in vitro cytotoxic effect of the antilymphocyte sera and its in vivo activity as measured by allogeneic graft survival.
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