Abstract
Summary
A study in young rats (weanling to 7 weeks of age) has shown that: (1) Liver mitochondria from rats with induced hyperthyroidism were less efficient as energy transducers than controls, as judged by lower P/O ratios. (2) Liver mitochondria from hyperthyroid rats contained more coenzyme Q than did controls. (3) Accordingly, coenzyme Q probably is not involved as an intermediate for phosphorylation; but rather, in the hyperthyroid state is in an alternate pathway of electron transport by-passing phosphorylation. (4) Methionine, under the conditions of the study, exerted no antithyrotoxic effect in terms of coenzyme Q content or P/O ratios of liver mitochondria.
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