Abstract
Summary
β,β′-Iminodipropionitrile (ID PN), previously thought to be exclusively a neurolathyrogen, was shown to be almost as potent an osteolathyrogen as β-aminopro-pionitrile (BAPN), as judged by the accumulation of soluble collagen in sponge-induced granulomas of IDPN-challenged rats. No significant changes in cathepsin, β-glucosaminidase, and acid phosphatase activities could be demonstrated in brain extracts of rats challenged with either IDPN or BAPN.
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