Abstract
Summary
The effect of a load of leucine on the metabolism of isoleucine was studied. Rats were fed L-isoleucine-(U)-14C and were given a load of leucine in gel form 12 hr later when the rate of 14CO2 expired had become constant. This resulted in a significant increase in 14CO2 expired, in every instance. This stimulation of the metabolism of isoleucine by a load of leucine offers an explanation for the previously observed depression of plasma isoleucine level after a load of leucine in human infants.
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