Abstract
Summary
With daily doses ranging from 0.037 mg for 9 days to 1.5 mg/100 g of body wt for 27 days, norethynodrel caused enlargement of prolactin cells as indentified by immunochemical staining. This reponse was especially prominent in ovariectomized rats. Hyperplasia of prolactin cells was not induced by norethynodrel which probably accounts for the absence of pituitary enlargement. The enlarged gonadotropin cells, presumed to be LH cells, that occur in ovariectomized rats were reduced in size by administration of norethynodrel. Norethynodrel induced little change in growth hormone and corticotropin cells.
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