Antilocalization of Cancer Cells Injected in Irradiated Area of Rats 1

Abstract

Summary

Walker 256 tumor cells were injected subcutaneously in an X-irradiated area of the right hip of Sprague-Dawley rats and in a corresponding nonirradiated area of controls. The tumors which developed in the injected areas were much larger in the controls than in the irradiated animals. The tumors were heavily encapsulated by fibrous tissue in the controls, but with little or no encapsulation in the irradiated animals. More viable cells and necrosis were present in the tumors of the controls. Special characteristics of the irradiated animals and not of the controls were invasiveness of the tumor and the presence of metastases.