Abstract
Summary
Autologous plasma was demonstrated both to sustain and inhibit human lymphocyte transformation in vitro. A plasma concentration of less than 1% was unable to adequately sustain PHA-induced transformation. However, by careful adjustments of PHA concentration, a plasma concentration of from 1 to 10% yielded optimum PHA-induced stimulation in the subjects tested. Optimum plasma levels were higher (10–25%) for candida-stimulated and for unstimulated lymphocyte transformation. Sub-optimum stimulation resulted when greater concentrations of plasma than the optimum were employed regardless of the stimulant. Considerable variation occurs between normal individuals in autologous plasma suppression of in vitro lymphocyte transformation.
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