Abstract
Summary
Weanling female Sprague-Dawley strain rats were given sc injections of 50 μg of mestranol, 1250 μg of norethynodrel or their combination three times weekly for 10 weeks, controls received vehicle. Anterior pituitary glands (AP) of each of the steroid-treated groups of donors were pooled for assay of GH content by measuring tibial epiphyseal cartilage width of hypophysectomized recipients. Recipients received four ip injections of AP homogenates containing a total of 1/4 AP, 1/2 AP, or 1 AP; control recipients received saline solution alone. As judged by tibial cartilage width of the recipients, the GH content of the AP of any of the three steroid-treated groups of donors decreased significantly as compared to that of the AP of the control donors.
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