Abstract
Summary
Changes which occur in hepatic lipid metabolism of hypophysectomized and bovine growth hormone-treated hypophysectomized rats were studied. Synthesis of lipids, as measured by the ability of tissue slices to incorporate 3H-glycerol into lipids, decreased rapidly following hypophysectomy. Three weeks after hypophysectomy, glycerol incorporation was approximately 40% of that in normal rats and remained depressed over the experimental period. Synthesis of acidic lipids was not appreciably affected by hypophysectomy but labeling of all other classes of lipids, particularly triglycerides, was diminished. Daily administration of bovine growth hormone over a 10-day period to animals 4-weeks posthypophysectomy resulted in a 75% increase in total lipid synthesis. Incorporation of label into the lecithin and cephalin fractions exhibited the greatest increase of those lipid fractions studied during the first 5 days of bovine growth hormone treatment.
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