Abstract
Summary
The effect of partial pancreatectomy, hypophysectomy, and hypophysectomy plus pancreatectomy on the incorporation of 35S sulfate into the aortic mucopolysaccharides of rats was studied. There was a marked peak in sulfate35 uptake 4 hr after the injection of the label in pancreatectomized and in hypophysectomized animals, and the appearance of this peak preceded the development of hyperglycemia in the pancreatectomized animals. In hypophysectomized-pancreatectomized animals, this peak was abolished. The findings suggest that insulin has an important role in vivo in the regulation of sulfate metabolism in vascular connective tissue. The results are discussed in relation to a possible interaction between growth hormone and insulin in the regulation of sulfate uptake and incorporation.
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