Abstract
Summary
Local anesthetics inhibited the clearance of 4-iodoantipyrine when injected into rat subcutaneous tissue. The order of potency for the inhibition was cocaine > prilocaine > lidocaine > procaine > tetracaine. This order is not the same as their local anesthetic potencies. The inhibition of clearance suggests that the local anesthetics have an effect on capillary uptake in the rat which is not related to their well-known vasodilator effect.
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